The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis
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چکیده
منابع مشابه
The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis
Endocrine cancers are a heterogeneous group of diseases that may arise from endocrine cells in any gland of the endocrine system. These malignancies may show an aggressive behavior and resistance to the common anticancer therapies. The etiopathogenesis of these tumors remains mostly unknown. The normal embryological development and differentiation of several endocrine glands are regulated by sp...
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IN 1998, ROSENFELD AND OH (9) likened insulin-like growth factors (IGFs) in endocrinology to the elephant in the parable of the blind men and the elephant. Since then, IGFs, and especially IGF-I, may have well become the elephant in other disciplines as well due to the numerous effects IGFs can exert in different tissues and cells. IGF-I is a pleiotropic peptide with tissueand cellspecific effe...
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Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions offering a range of important therapeutic applications. To evaluate a system for large-scale production of this peptide in the mammary glands of transgenic livestock, we generated transgenic rabbits carrying fusion genes in which a synthetic DNA coding for human IGF-I (hIGF-I) was placed...
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ژورنال
عنوان ژورنال: Journal of Oncology
سال: 2012
ISSN: 1687-8450,1687-8469
DOI: 10.1155/2012/635614